Centre of Excellence (COE) – HIV Care
Protozoology
Professor & In-charge : Prof. Pratip Kumar Kundu
Reader : Dr. A.K. Maji
Assistant Professor : Dr. Swagata Ganguly
Medical Technologist : Mr. Asish Bhowmik
  : Mr. Ajit De
  : Mr. Ritick Paul
G.D.A. : Mr. Dilip Kumar Das
CT & SW : Mr. Bhola Heal

Departmental (Unit) Activities :

a)   Patient Care Services:
Routine clinical & diagnostic service to the patient – the unit provides diagnostic & clinical service to the patient throughout the year on Malaria, Kala-azar and other protozoan infections. It also serves as a referral unit for protozoan infections.     

Incidence of malaria detected and treated at Malaria Clinic, CSTM, 2012

Protozoology Unit

Month Total No. Examined P.Vivax P. Fal Mixed Total Positive SPR
January 458 53 21 1 75 16.38
February 592 58 2 1 61 10.30
March 540 94 2 0 96 17.78
April 513 143 1 0 144 28.07
May 578 150 0 0 150 25.95
June 771 152 0 0 152 19.71
July 1273 225 1 0 226 17.75
August 1994 565 46 0 611 30.64
September 3746 978 167 2 1147 30.62
October 2382 416 183 4 603 25.31
November 1348 228 196 1 425 31.53
December 528 3 1 0 4 0.76
Total 14723 3065 620 `9 3694 25.09

b) Routine diagnostic service to the patients of Kala-azar / rk-39 test for the Year 2012:

Kala Azar

Month Total Examined Total Positive % of positive
January 14 2 14.29
February 32 12 37.50
March 35 4 11.43
April 33 6 18.18
May 32 0 0.00
June 25 4 16.00
July 27 7 25.93
August 42 4 9.52
September 47 7 14.89
October 37 3 8.11
November 42 8 19.05
December 42 6 14.29
Total 408 63 15.44

C) Kala-Azar detection from Bone marrow / Spleen Biopsy for the Year 2012 :

Total Number of Cases Positive PR
31 9 29.03

d)   Routine diagnostic service to the patients of G6PD for the Year 2012:
Calcutta School of Tropical Medicine for the year 2012
G6 PD

Month Total Examined Normal Deficient % of positive
January 34 34 0 0.00
February 33 33 0 0.00
March 34 34 0 0.00
April 60 60 0 0.00
May 35 35 0 0.00
June 53 52 1 1.89
July 11 11 0 0.00
August 8 6 2 25.00
September 10 10 0 0.00
October 6 6 0 0.00
November 12 12 0 0.00
December 8 8 0 0.00
Total 304 301 3 0.99

Teaching Activities :
Regular teaching of MD, DTM&H, DCP and DLT Students.

Public Health related Training :   

  • In the year 2012 the unit took part in training programmes on “ Training on Malaria Microscopy for the Laboratory Technician” from June, 2012 to July, 2012 in 10 Batches, Organized by the Calcutta School of Tropical Medicine and supported by National Rural Health Mission, Govt. of West Bengal. Prof. P.K. Kundu acted as training co-ordinator.
  • In December 2012, the unit took part in a special Kala-azar elimination programme at Munni Division of Gunguram Tea Estate, Phansidewa Block, Darjeeling District as per order of Director of Health services, Government of West Bengal.

Prof. P.K. Kundu, Dr. A.K. Maji, Dr. S. Ganguly, Mr. A. Bhowmik and Mr. R. Paul acted as resource persons.

Research :
Research projects:

Title of the project Sponsoring Agency Total period with dates
“Role of detection and treatment of asymptomatic cases of P. falciparum to eliminate malaria : a pilot study in Jalpaiguri and Purulia district, West Bengal.” Department of Health and Family Welfare, Govt. of West Bengal December 2011 – Nov 2012
“Role of rapid diagnostic kit and oral miltefosin to control leishmaniasis in Tribal Population of  South Bengal.” Indian Council of Medical Research (ICMR) May 2012 – till date (3yrs. Project)

Thesis work under supervision :

  1. “Studies on drug resistant Malaria in Jalpaiguri” by Mrs. Shrabanee Mullick, Ph.D. Thesis. University of Jadavpur. (Ph.D awarded)
  2. “Prevalence of DHFR and DHPS mutation and its association with sulphadoxine pyrimethamine resistance of P. falciparum in West Bengal , by Mrs. Sonali Das , Ph. D. Thesis. University of Calcutta (In Progress).
  3. PREVALENCE OF Plasmodium falciparum CHLOROQUINE RESISTANT TRANSPORTER (Pfert) GENE MUTATIONS AND ITS ASSOCIATION WITH IN-VIVO CHOLOQUINE RESISTANCE IN WEST BENGAL, INDIA. By Mr. Pabitra Saha. Ph.D. Thesis. University of Calcutta. (Thesis Submitted )
  4. Prevalence of CQ resistance malaria in a tertiary care hospital. By Dr. Soma Dutta , M.D. Thesis. University of Health Sciences. (passed MD)
  5. Therapeutic efficacy of Artesunate  + Mefloquine in Uncomplicated P. falciparum  Malaria in Kolkata by Dr. S. Roy , MD Thesis. University of Health Sciences (Passed MD).
  6. Studies on P. vivax Malaria in Kolkata with special reference to clinical manifestation and relapse. By Dr. S. Kumar. MD Thesis. University of Health Sciences (Passed MD).
  7. Studies on P. vivax Malaria in Urban Population of Kolkata with special reference to Chloroquine Sensitivity and Relapse Pattern by Dr. S. Ganguly, Ph.D Thesis , The West Bengal University of Health Sciences (In Progress).
  8. Comparison of the diagnostic methods of Malaria :Microscopy , Immunochromatography and PCR  by Dr. P. Saha, MD Thesis. University of Health Sciences (In Progress).
  9. Study on Kala-azar and Post Kala-azar Dermal Leishmaniasis cases in Malda district  and  CSTM  in  relation  to rkE16 antibody positivity by Dr. S. Maiti, MD Thesis. University of Health Sciences (In Progress).
  10. Study on the prevalence of Plasmodium falciparum Chloroquine resistance transporter gene mutation and its association with therapeutic efficacy of Chloroquine in Kolkata by Dr. N Dawar, MD Thesis. University of Health Sciences (In Progress).

Other Academic Activities:

  • Prof. P.K. Kundu acted as External Examiner in MBBS and DMLT Examination of various Universities.

Dr. S. Ganguly participated in the following activities:

  1. Completed Winter School on “Genetic Dissection of a Complex Disease: Analytical Approaches”, January 3 – 10, 2012 organised by National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, India, supported by Wellcome Trust/ DBT India Alliance.
  2. Indian Pharmacological Society, West Bengal Chapter, 21st Annual Conference, 14th January 2012, organised by Deptt. of Clinical & Experimental Pharmacology, CSTM, Kolkata – presented paper entitled “genetic markers: a new tool in monitoring antimalarial drug resistance of P.  falciparum MALARIA.”
  3. National Symposium on Frontlines of Microbiological Research: Concepts and Applications, 2nd–4th February, 2012, organized by Indian Mycological Society, in collaboration with Deptt. of Botany, University of Calcutta, presented paper entitled “EVALUATION OF DIAGNOSTIC METHODS OF CRYPTOCOCCAL INFECTION  IN IMMUNOCOMPROMISED INDIVIDUALS  IN A TERTIARY CARE HOSPITAL : TEN  YEARS  STUDY.”
  4. Attended APRICON, 14th National Conference on Rabies, 7th -8th July, 2012.
  5. Completed Course on “Laboratory Quality Management & Internal Audit”, 27th – 30th August, 2012 organised by CETE, Bangalore, supported by STQC Directorate, Deptt. of Electronics & Information Technology, Ministry of Communication & Information Technology, Government of India.
  6. Completed Laboratory Training Course on “Application of Genomics Technologies in Malaria Research” 18th November- 1st December, 2012 organised by National Institute of Malaria Research, New Delhi, India supported by DBT.
  7. MICROCON, 36th National Conference of Indian Association of Medical Microbiologists, 22nd 25th November, 2012 organised by Deptt. of Microbiology, Lady Hardinge Medical College, presented paper entitled “ASYMPTOMATIC MALARIA: A  BIG  OBSTACLE  TO ELIMINATE  MALARIA.”

Mr. Pabitra Saha,  participated in the National Conference of IAMM, Microcon 2012on 22nd  to 25th November, 2012 and presented a poster entitled “A High Prevalence of Leishmania Infection in a Tribal Village in Malda District, West Bengal, India.”
He completed Winter School on “Genetic Dissection of a Complex Disease: Analytical Approaches”, January 3 – 10, 2012 organised by National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, India, supported by Wellcome Trust/ DBT India Alliance..   

Publications in referred Journals:

  1. Kumar AChery LBiswas CDubhashi NDutta PDua VKKacchap MKakati SKhandeparkar AKour DMahajan SN,Maji AMajumder PMohanta J,Mohapatra PKNarayanasamy KRoy KShastri JValecha NVikash RWani RWhite J,Rathod PK.(2012). Malaria in South Asia: prevalence and control. Acta Trop.121:246-255.
  2. Saha P, Guha SK, Das S, Mullick S, Ganguly S, Bera DK., Biswas A, Chattopadhyay G, Das M, Kundu PK, Ray K and Maji AK.(2012). Comparative efficacy 1 of Artemisinin Combination Therapies (ACTs) in P. falciparum malaria and polymorphism of PfATPase6, Pfcrt, Pfdhfr and Pfdhps genes in tea gardens of Jalpaiguri district, India. Antimicrobial Agent and Chemotherapy. 56: 2511-2517
  3. Patra P, Guha SK, Maji AK, Saha P, Ganguly S, Chakraborty A, Kundu. PK , Sarkar S. and Ray K. (2012). Efficacy of oral miltefosine in visceral leishmaniasis in rural West Bengal, India. Indian J Pharmacol. 44:500-503.
  4. Kim JR, Nandy A, Maji AK, Addy M, Dondorp AM, Nicholas PJD, Pukrittayakamee S, White NJ  and Imwong M. (2012) Genotyping of Plasmodium vivax Reveals Both Short and Long Latency Relapse Patterns in Kolkata. PLoS ONE 7(7): e39645. doi:10.1371/journal.pone.0039645
  5. Patil RR, Muliyil J, Nandy A, Addy A, Maji AK and Chatterjee P. (2012) Dynamics of the antibodies in cohorts of cured cases of visceral leishmaniasis: Its implication on the validity of serological test, value in prognosis and in post therapeutic assessment. Human Vaccines & Immunotherapeutics 8:725-730.
  6. Basu M, Das T, Ghosh A, Majumder S, Maji AK, et al. (2012) Gene-Gene Interaction and Functional Impact of Polymorphisms on Innate Immune Genes in Controlling Plasmodium falciparum Blood Infection Level. PLoS ONE 7(10): e46441. doi:10.1371/journal.pone.0046441
  7. Ganguly S, Saha P, Guha SK, Das S, Bera DK, Biswas A, Kundu PK, Saha B, Ray K and Maji AK.(2012)In vivo therapeutic efficacy of chloroquine alone or in combination with primaquine in vivax malaria in Kolkata, West Bengal, India and polymorphism in pvmdr1 and pvcrt-0 genes. Antimicrobial Agent and Chemotherapy. December 2012, doi: 10.1128/ AAC.02050-12.
  8. Saha P, Naskar A, Ganguly S, Das S, Guha SK., Biswas A, Bera DK, Kundu PK, Das M, Mullick S, Ray K and Maji AK.(2012) Therapeutic efficacy of Artemisinin Combination Therapies and prevalence of S769N mutation in PfATPase6 gene of P. falciparum in Kolkata, India. Asian Pacific Journal of Tropical Medicine. ( In Press).
  9. Basak S, Thoudam PD, Mukherjee M, Ganguly S, Majumdar M, Bhattacharya S, Saha B, Pal D. (2012) Study on isolation of Cryptococcus neoformans form human and animals and its correlation with human infection with special reference to HIV / AIDS patients. J. Mycopathological Research. 50 (2): 261 -265.
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