Centre of Excellence (COE) – HIV Care
Biochemistry and Medical Biotechnology
NAME OF FACULTY DESIGNATION PHONE NO. E mail
Dr. Mandira Mukherjee Head of the Department, Associate Professor 9433948556 mandira_71@yahoo.com
Dr. Sujata Law Assistant Professor (Stem Cell Biology) 9051259018 msuj2002@yahoo.co.in
Dr. Anusri Tripathi Assistant professor (Molecular Biology) 9073365665 anusri.stm@gmail.com
Dr. Biswanath Chakraborty Chemist 9874066558 chakrabarty69@gmail.com
Dr. Anjan Kumar Basu Demonstrator 9832204562 anjkb@yahoo.co.in

Other Permanent Staffs:
Medical Laboratory Technologist : Jayeeta Das

Group D Attendant :
Sikander Ram Dhurpa Soren

PGT/RA/SRF/JRF/ Other:

Name Designation PhD. Supervisor
Shreya Basu SRF Dr. Mandira Mukherjee
Sudip Kumar Dutta SRF Dr. Anusri Tripathi 
Lena Dhara SRF -do- 
Sandip Kumar Mukherjee SRF Dr. Mandira Mukherjee
Biplab Ghosh SRF -do- 
Sukalpa Chattopadhyay SRF(INSPIRE) Dr. Sujata Law
Arijit Pal SRF Dr. Anusri Tripathi
Shalini Sanyal SRF(INSPIRE) Dr. Sujata Law
Suchismita daw SRF(INSPIRE) -do- 
Sayantan Mukherjee SRF -do- 
Debojyoty Bandyopadhyay JRF Dr. Mandira Mukherjee
Arunita Ghosh JRF(INSPIRE) -do- 
Saikat Mukherjee JRF Dr. Anusri Tripathi
Snehashis Koley JRF Dr. Mandira Mukherjee

Teaching:
The department conducts a specialized course of teaching ‘M.Sc. in Medical Biotechnology’ affiliated under West Bengal University of Health Sciences [WBUHS] with a capacity of ten students per year. The duration of the course is two years. The syllabus for the 1st year includes Biochemistry, Cell biology, Molecular Biology and Microbial Genetics and for the 2nd year includes Immunology and Immunogenetics, Bioinformatics and Gene Based Diagnosis and Therapy. Faculties of this department are also engaged in conducting theory and practical classes in Biochemistry of the BSc. Medical Laboratory Technology (BMLT) course & Diploma in Clinical Pathology (DCP).

On Going Training Programme:
The department is involved in conducting short term project works of M.Sc./ B.Tech. /Post M.Sc students from different universities in India

Research Activities: Dr. Mandira Mukherjee

Research projects

1. Studies on universal stress protein (UspA) in clinical isolates of multidrugresistant uropathogenic Escherichia coli – A study from West Bengal. DST, Govt of India, 2015; Principal Investigator

2. Molecular characterization of AmpC beta-lactamase producing multidrug resistant uropathogenic E. coli – A study from Kolkata, an eastern region of India. Science & Engineering Research Board (SERB), New Delhi, DST, Govt. of India, 2017; Principal Investigator

3. Antibiotic resistance in clinical isolates of uropathogenic Escherichia coli - Understanding the role of universal stress protein A (UspA) as a target for therapeutic intervention. DBT, Govt. of West Bengal, 2018; Principal Investigator

Publications (last three years)
1. Basu S, Mukherjee M*. 2018 Incidence and risk of co-transmission of plasmid mediated quinolone resistance and extended spectrum ß-lactamase genes in fluoroquinolone resistant uropathogenic E. coli : a first study from Kolkata, India J Glob Antimicrob Resist. Mar; doi: 10.1016/j.jgar.2018.03.009

2. Mukherjee SK, Mandal RS, Das S, Mukherjee M*. 2018 Effect of non-ß-lactams on stable variants of inhibitor-resistant TEM ß-lactamase in uropathogenic Escherichia coli: implication for alternative therapy. Journal of Applied Microbiology. Mar;124(3):667-681. doi: 10.1111/jam.13671

3. Mukherjee S K, Mukherjee M*. 2017 “Potential plasmidic co-transfer, extended spectrum ß-lactamase lineage and integron association in uropathogenic E. coli from an endemic region International Journal of Current Research, 9, (11), 61054- 61059, ISSN: 0975-833X

4. Bandyopadhyay D, Mukherjee M*.2017 Distribution of class d oxacillinases amongst third generation cephalosporin resistant nosocomial uropathogenic Escherichia coli isolates, their phylogenetic background and clonal analysis. International Journal of Current Research 9, (10), 59099-59106, ISSN: 0975-833X

5. Ghosh B, Mukherjee M* 2016 Emergence of co-production of plasmid-mediated AmpC beta-lactamase and ESBL in cefoxitin-resistant uropathogenic Escherichia coli European Journal of Clinical Microbiology and Infectious Disease; DOI 10.1007/s10096-016-2683-z

6. Mukherjee M*, Koley S, Mukherjee SK, Basu S, Ghosh B, Chakraborty S 2015 Phylogenetic background of E. coli isolated from asymptomatic pregnant women from Kolkata,India Journal of Infection in Developing Countries; 9(7):720-724

Research Activities: Dr. Sujata Law

Research projects

1. “Regulatory approach of stem cells and stem cells niche in Leukemia, Aplastic anemia and Myelodysplastic syndrome (MDS): A diagnostic and therapeutic intervention ” DBT, Govt. of West Bengal , 2013-2016; Principal Investigator

2. “Association of Fetuin-A and DPP-4 in adult with glucose intolerance” RSSDI, Govt. of West Bengal, 2016; Co Investigator

3. “An experimental approach towards Bone marrow and microenvironment in Leukemia by using Ashwagandha (Withania somnifera) and Bhringaraj (Eclipta alba): Two candidate inhibitors of Hedgehog and NF-?ß pathways”. AYUSH (CCRAS), Govt. of India, 2017-2020; Principal Investigator

4. Characterization of Cord Blood-derived Plasma Factor (CBPF) And Associated Environment and Analysis of Growth factor/Cytokine Profile Including Cellular Behaviour for Therapeutic Hint. DBT, Govt. of West Bengal, 2018-2021; Principal Investigator

Publication (last three years):

1.Epigenetic and Microenvironmental alterations in bone marrow associated with ROS in experimental Aplastic Anemia. Ritam Chatterjee, Sujata Law*. European Journal of Cell Biology(Elsevier).2018.

2.Chronic Pesticide Exposure and Consequential Keratectasia & Corneal Neovascularisation. Shalini Sanyal, Sujata Law*. Experimental Eye Research (Elsevier). 164 (2017) 1e7, 2017.

3.Hematopathological alterations of major tumor suppressor cascade, vital cell cycle inhibitors and hematopoietic niche components in experimerimental myelodysplasia. Ritam Chatterjee, Shubhangi Gupta, Sujata Law*. Chemico Biological Interactions. (Elsevier) , 273 (2017) 1e10. 2017.

4. Microenvironmental scenario of the Bone Marrow of inorganic Arsenic Exposed Experimental Mice. Jacintha Archana Pereira, Sujata Law*. Biological Trace Element Research. (Elsevier) DOI 10.1007/s12011-017-1022-2, 2017.

5.Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental Myelodysplastic syndrome. Suchismita Daw, ,Ritam Chatterjee, Aditya Law, Sujata Law*. Chemico Biological Interactions . DOI: org/10.1016/j.cbi.2016.10.010. 2016, 260 , 176-185, 2016.

6.Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/ progenitor compartment leads to cellular catastrophe in experimental aplastic anemia. Ritam Chatterjee, Sukalpa Chattopadhyay, Sujata Law*.Molecular and Cellular Biochemistry. DOI: 10.1007/s11010-016-2811-1.2016.

7.Alteration of Classical and Hematopoiesis Specific p53 Pathway in the Bone Marrow Hematopoietic Stem/Progenitor Compartment Facilitates Leukemia Progression in Experimental Mice. Ritam Chatterjee, Sukalpa Chattopadhyay, Sujata Law*. Leukemia Research (10.1016 /j.leukres .2016. 05. 014) ,47 , 70–77, 2016.

8.Effect of chronic pesticide exposure on murine cornea: A histopathological, cytological and flowcytometric approach to study ocular damage by xenobiotics. Shalini Sanyal, Prosun Das, Sujata Law*. Cell Biology and Toxicology (Springer).32(1), 7-22, DOI: 10.1007/s10565-016-9314-4. 2016.

9.Differential expression of mitotic regulators and tumor microenvironment influences the regional growth pattern of solid sarcoma along the cranio-caudal axis . Sukalpa Chattopadhyay 1 , Malay Chaklader 1,2 , Ritam Chatterjee, Sujata Law*. Experimental Cell Research , http://dx.doi.org/10.1016/j. 2016.

10. Book Chapter: Human Stem Cell Toxicology .Chapter 7. Pesticide and Hematopoietic Stem Cells. Sujata Law*and Malay Chaklader. Royal Society of Chemistry, London, UK. 2016.

11. Non-Canonical Wnt5a-Ca2+-NFAT Signaling Axis in Pesticide Induced Bone Marrow Aplasia Mouse Model: A Study to Explore the Novel Mechanism of Pesticide Toxicity. Sukalpa Chattopadhyay, Ritam Chatterjee, Sujata Law*. Environmental Toxicology.2015.

12. Limbal epithelial stem-microenvironmental alteration leads to pterygium development.. Prosun Das, Arjun Gokani, Ketaki Bagchi, Gautam Bhaduri ,Samaresh Chaudhuri,Sujata Law *.Molecular and Cellular Biochemistry . DOI: 10.1007/s11010-014-2320-z. 2015.

13. Pathophysiological Scenario of Hematopoietic Disorders: A Comparative Study of Aplastic Anemia, Myelodysplastic Syndrome and Leukemia in Experimental Animals. Ritam Chatterjee ,Sukalpa Chattopadhyay ,Shalini Sanyal, Suchismita Daw, Sujata Law*.Proceedings of the Zoological Society. DOI: 10.1007/s12595-014-0132-5. 2015.

14. Alteration of Hedgehog signaling by chronic exposure to different pesticide formulations and unveiling the regenerative potential of recombinant Sonic Hedgehog in mouse model of bone marrow aplasia. Malay Chaklader, Sujata Law*. Molecular and Cellular Biochemistry, 401 ( 1) , Pg 115-131. (DOI)10.1007/s11010-014-2299-5.2015.

Research Activities: Dr. Anusri Tripathi

Research projects

1. Molecular understanding of the antimicrobial property of natural compounds- eugenol and cinnamaldehyde against multidrug resistant pathogenic Enterobacteriacrae. Funded by Indian Council of Medical Research; 2015. Principal-investigator.

2. Molecular understanding of Metallo-Beta-Lactamase mediated carbapenem resistance development among Gram-negative bacteria and identification of inhibitory compounds against them. ICMR-JRF; 2012. Supervisor.

3. Early detection of Chikungunya cases among population of Kolkata and adjoining districts. Funded by Department of Science and Technology, Govt. of West Bengal; 2014. Co-Principal investigator

Publication (last three years)

1. Dutta SK, Tripathi Anusri*. Association of toll-like receptor polymorphisms with susceptibility to Chikungunya virus infection. Virology; 2017; 511: 207-213.

2. Mukherjee S, Dutta SK, Sengupta S, Tripathi Anusri*. Evidence of Dengue and Chikungunya virus co-infection and circulation of multiple dengue serotypes in a recent Indian outbreak. European Journal of Clinical Microbiology and Infectious Disease; 2017; 36(11): 2273-2279.

3. Pal A, Tripathi Anusri*. An in silico approach to elucidate structure based functional evolution of Oxacillinase. Computational Biology and Chemistry; 2016; 64: 145-153.

4. Pal A, Dhara L, Tripathi Anusri*. Major contribution of AcrB upregulation and OmpC/Ompk36 loss over presence of blaNDM towards carbapenem resistance development among pathogenic Escherichia coli and Klebsiella spp. Indian Journal of Medical Research (In press).

Research Activities: Dr. Biswanath Chakraborty

Publication (last three years):

Evaluation of antimicrobial activity of synthesized fluorocarbazole derivatives based on SAR. Suchandra Chakraborty, Biswanath Chakraborty, Ahana Saha, Chandan Saha, Tamal Kanti Ghosh & Indrani Bhattacharyya Indian Journal of Chemistry, 2017, Vol.56B, 701-708.

Research Activities: Dr. Anjan Kumar Basu

Publication (last three years):

Molecular analysis and identification of vancomycin resistant genes (vanA, vanB) and Tn1546 like elements among methicillin resistant Staphylococcus aureus (MRSA) isolates from patient sample in kolkata- an emerging threat. Manisha Chakraborty, Anjan Kumar Basu*. Journal of Biotechnology and Biosafety. 2015 Vol. 3 Issue 5 Sep/Oct. 308-318

Other Activities:

Dr. Biswanath Chakraborty and Dr. Anjan Kumar Basu are involved in Quality Control assistance and additionally provide technical support to the Department of Laboratory Medicine, School of Tropical Medicine, Kolkata

 

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